The actress appears as you have never seen before, playing the mother of three in a moving story about a family living with cancer.
In My Sister's Keeper, adapted from Jodi Picault's best-selling book, Cameron's character Sara shaves off her famous blonde locks in a show of solidarity with her eldest daughter Kate, who is suffering from leukaemia.
The film tells the story of the Fitzgerald family, who conceived their youngest child Anna (Abigail Breslin) as a genetic match for Kate (Sofia Vassilieva).
Since the moment she was born, Anna has donated blood, bone marrow and her umbilical cord to help prolong her sister's life.
In the introduction to the trailer, Abigail provides the voiceover introducing viewers to her character's plight.
She said: 'Most babies are accidents. Not me. I was engineered. Born to save my sister's life...'
After initial surprise that a 13-year-old wants to sue her parents, Campbell comes to understand her predicament and agrees to represent her for free.
The lawsuit threatens to destroy the family and Sara's marriage to husband Brian (Jason Patric) as they fight over how to deal with Kate's illness.
Meanwhile, the couple's son Jesse (Evan Ellingson) is feeling ignored amongst all the focus on his sisters and turns into a pyromaniac.
While Anna and Kate have a strong sisterly bond, the 13-year-old is exasperated when her parents want to to donate her kidney to her sibling when she suffers renal failure.
In a shocking twist which raises questions about the ethics of genetically-engineered 'donor babies', Anna decides to sue her parents to become medically emancipated from her parents so she can take charge of her body.
Anna hires hot shot lawyer Campbell Alexander, played by 30 Rock star Alec Baldwin, to fight her case.
The moving film is expected to become the biggest movie tearjerker this year when it is released this summer.
Author Jodi recently admitted fans of her book may be surprised because film producers had changed the ending for the big screen.
She said: 'Having the ending changed would certainly not have been my choice. I wrote the ending very intentionally because I wanted to leave the reader with a certain message. And changing that ending changes that message.
'However, I am excited to see the movie and to judge it on its strengths.'
The film also stars Thomas Dekker, 21, as Kate's first love and fellow cancer patient, and Joan Cusack as the judge who oversees the trial.
The film is set for release in the UK on June 26.
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